Topic of Research Seminar: Peptide Synthesis and oxetane containing short fragments

Abstract: Peptide analogues are extremely important in medicinal chemistry offering several advantages over physiologically active peptides. Consequently, there is an ongoing search for new motifs that effectively mimic the structure and conformation of natural peptides. A highly productive approach is to replace one or more of the amide bonds of the backbone with a peptide bond isostere such as an E-alkene, thioamide or sulfonamide. Since the four membered oxetane ring has emerged as an excellent replacement for the carbonyl group in medicinal chemistry it is reasoned that substituting one or more of the C=O bonds within the backbone of a peptide with oxetane units could yield an interesting new class of peptide related molecules with greatly reduced vulnerability to proteases.

Subject Field of Topic: Chemistry

Name of Speaker: Mr. Naeem Ahmad

Professorial Rank of Speaker: PhD Scholar (Chemistry Dpt.) SNS – NUST

Email of Speaker: [email protected]

Affiliation of Speaker: School of Natural Sciences (SNS), NUST

Date and Venue: (Thursday) 09 May 2024, 14:00 hrs, at CR # 205 (New Building SNS), School of Natural Sciences (SNS), NUST Islamabad