Topic of Research Seminar: Bifunctional and Synergic Surface Modifications of Biomedical Implants for Improved Biocompatibility
Abstract: Development and fabrication of medical implants to monitor or treat the damaged or missing body part is becoming an important field of medical because of increasing aged population which is more susceptible to chronic diseases. However, tissue damage during implantation and the continuous presence of the foreign device in the body can trigger a cascade of events, which lead to negative foreign body which may result in loss of functionality and implant failure. Initially, different methods were used for the suppression of inflammation and fibrous encapsulation at the implant vicinity over an extended period to ensure the long-term functionality of implants; however, these implants were able to suppress only one activity and were susceptible to be destroyed by another phenomenon. Thus, there is a need to develop multifunctional biomedical devices comprising of different biomaterials which could synergically work and inhibit more than one biological activities. The objective of this study was to develop a multifunctional biomedical implant surface which had anti-coagulation, anti-thrombosis, anticorrosive and anti-material leaching properties. The graphite based passively modified surface was coated with PLA based active coating and resulting surface had excellent anti-coagulation, platelet adhesion inhibition, anti-corrosive and anti-material leaching properties which could potentially reduce the rate of adverse effects of medical device implantation and implant failure. In a nutshell, the natural drug loaded graphite-based coating can simultaneously enhance the anti-coagulation, blood compatibility and anti-corrosion properties of biomaterials. Because the PVD based modifications and polymeric coatings can be easily prepared on most of biomaterials including polymer, ceramics and metal, thus the approach of the present study may open up a new window of promising an effective and efficient way to promote improve the blood compatibility of blood-contact biomedical devices and implants.
Subject field of Topic: Biomaterials, Biomedical Implants, Medical devices
Name of Speaker: Sadia Hassan
Professional Rank of Speaker: PhD student
University Email of Speaker: firstname.lastname@example.org
Research Group Weblink: https://scholar.google.com/citations?hl=en&user=ensNuR4AAAAJ
Affiliation of Speaker: NUST School of Mechanical and Manufacturing Engineering (NUST-SMME)
Date and Venue: October 10, 2022, 1700 – 1630 hrs, NUST School of Mechanical and Manufacturing Engineering (NUST-SMME), NUST Islamabad Campus.