Topic of Research Seminar: Sustainable metal and base-free direct amidation of esters using water as a green solvent

Abstract: Amides are the most important functional group in both chemistry and biology, and they play a distinct role in the pharmaceutical industry. Amide bond formation is a common process that involves coupling reagents such as metal catalysts and additives. In this regard, we present a straight forward and effective synthetic strategy for direct amidation by breaking the C(acyl)–O bond without the need for extra reagents or catalysts, using only water as an environmentally friendly solvent, which gives the necessary compounds in good to outstanding yields. This approach is notable for its lack of metals, additives, and bases, as well as its use of water as a green solvent. As a result, it represents a novel and environmentally benign method of achieving direct amide bond synthesis. Using this approach, approximately 30 distinct amides were reported, including the medicinal compound Diethyltoluamide, in good yield. Finally, this method was successfully used to the gram-scale synthesis of a representative amide product

Subject Field of Topic: Chemistry

Name of Speaker: Mr. Naeem Abbas

Professorial Rank of Speaker: PhD Student (Chemistry Dpt.) SNS – NUST

Email of Speaker: [email protected]

Date and Venue: (Thursday) 17 October 2024, 14:00 hrs, at CR #205 (New SNS Building), School of Natural Sciences, NUST Islamabad