Topic of Research Seminar: Synthesis of Novel Calcium Phosphate based composites for bone tissue regeneration
Abstract: Whitlockite (WH), being the second most abundant bio-mineral in bone, finds enormous potential for bone tissue regeneration. However, owing to its structural similarity with β-TCP and its difficulty in synthesis, this material has not been explored extensively. Here in this work, we report the synthesis of single-phase WH in bulk using two different methods i.e., the wet precipitation method and the solid-state method. The effect of different parameters like precursors type, feed rate, precursor ratios, aging time, heating time, and heating conditions has been studied in detail and exact conditions for the synthesis of single-phase WH in bulk have been reported. The prepared WH was characterized by using FTIR, Raman spectroscopy, x-ray diffraction (XRD), Transmission microscopy (TEM), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The characterization results confirmed the synthesis of single-phase WH with a nanometer size range by both methods. The biological potential of these WH was evaluated using in-vitro bioactivity tests and cell studies. WH prepared by both methods showed excellent bioactivity after immersion in SBF as well as good cell adhesion and proliferation for MC3T13 osteogenic cells. To further evaluate the suitability of WH for practical applications, its chitosan-based composites were coated on titanium plates. The Taguchi model was employed to find out the ideal economical coating conditions. The prepared coatings showed controlled degradation, good adhesion, bioactivity, cell growth, surface roughness, and hydrophilicity. Thus, WH prepared by both methods could be an ideal material for the fabrication of scaffolds for bone tissue regeneration applications.
Subject Field of Topic: Biomaterials/Nanomaterials
Name of Speaker: Sadaf Batool
Professorial Rank of Speaker: Ph.D. Scholar
University Email of Speaker: [email protected]
Affiliation of Speaker: NUST School of Chemical and Materials Engineering (NUST-SCME)
Date and Venue: February 14, 2023, at 1400 hrs, SCME Seminar Hall, School of Chemical and Materials Engineering (SCME), NUST Islamabad Campus